Liver disease and the microbiome: NAFLD and NASH

In my video on liver health, I take you through detailed explanations of what’s going on, primarily in the context of NAFLD and NASH. This video is applicable to so many people, of all ages.  

When you think of the liver, you probably think about it as the filter of the body – removing toxic compounds. Something you learned years ago. And that’s very true. But the liver is incredibly active and plays roles in so many aspects for which you are not aware. For example, it makes bile acids. OK, so those are just to help with fat absorption, what’s the big deal. Well, they are powerful hormones which link many different parts of the body. And the microbiome plays a huge role in determining the composition of these bile acids. We could say so much more about the liver, but to dial in for our purposes here, we’ll highlight its direct connection to the gut. When we think of veins, we think of the circulatory system returning blood to the heart. But there is one exception to this rule, what’s called the portal vein, which brings blood along with a slew of actors directly from the gut to the liver. This portal vein is a highway for the three main topics of the presentation, fructose, bile acids and components of the microbiome. You’ll learn how these three key factors play a huge role in liver disease.  

As in all of my videos, I provide the scientific evidence to support what I’m saying. Is anyone else doing this? I realize my content can be a bit dense, but for a certain percentage of people, and it’s small, it’s right up their alley. I find that in general, when I conduct my consultations with individuals who have found me via my videos, they are very well versed in their respective condition, as well as nutrition and other aspects of health. In fact, I’d place bets that some of them know more about their condition than do their practitioners. With that said, they look to learn something new. If the content were any less, I’d be like everyone else online, and you would wonder how I can call myself The Microbiome Expert. So, if my videos are not for you, I understand. But if you are one of those people taking a vested interest in their health, and are looking for a more intelligent way forward, then “welcome”. 

As the former director of medical education for a microbiome firm, and now with my own platform, I have helped many people over the years. And now, I bring this knowledge directly to you. In our world as it is, we all now have to be our own health advocates. With a broken government, food and medical system, you need to take charge of your healthcare. So, educate yourself, as best you can. This is why I’ve launched my educational platform. You can find my presentations entitled, “Liver Health – NAFLD and NASH” in my Microbiome University tab, and also on my YouTube channel. If you have a condition or disease that you think would be well served by addressing your microbiome, you can visit the Protocols tab on my website where you can find a science-based protocol which may dramatically improve your quality of life, as they have done for many others (see my testimonials) 

The references cited within this video presentation 

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts – PubMed (nih.gov) 

Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease – PubMed (nih.gov) 

The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis – PubMed (nih.gov) 

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease – PubMed (nih.gov) 

Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications – PubMed (nih.gov) 

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids – PubMed (nih.gov) 

Dynamics of the enterohepatic circulation of bile acids in healthy humans – PubMed (nih.gov) 

Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications – PubMed (nih.gov) 

Role of Intestinal Microbes in Chronic Liver Diseases – PubMed (nih.gov) 

Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature – PubMed (nih.gov) 

Plasma concentrations of zonulin are elevated in obese men with fatty liver disease – PubMed (nih.gov) 

Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis – PubMed (nih.gov) 

Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis – PubMed (nih.gov) 

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH – PubMed (nih.gov) 

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae – PubMed (nih.gov) 

Mitochondrial Dysfunction is a Key Pathway that Links Saturated Fat Intake to the Development and Progression of NAFLD – PubMed (nih.gov) 

Structural and Functional Alterations of Gut Microbiota in Males With Hyperuricemia and High Levels of Liver Enzymes – PubMed (nih.gov) 

Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age – PubMed (nih.gov) 

Childhood Fructoholism and Fructoholic Liver Disease – PubMed (nih.gov) 

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease – PubMed (nih.gov) 

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD) – PubMed (nih.gov) 

Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents – PubMed (nih.gov) 

Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents – PubMed (nih.gov) 

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